Substituted 4,10-dihydro-10-oxothieno benzoxepins

Details Substituted 4,10-dihydro-10-oxothieno benzoxepins Substituted 4,10-dihydro-10-oxothieno benzoxepins

1984-08-10

1985-04-30

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548237, A61K 3142, C07D49504

Patent

active

045144117

ABSTRACT:
This invention relates to substituted 4,10-dihydro-10-oxothieno benzoxepins of the formula, ##STR1## where R is hydrogen and lower alkyl; R.sub.1 is ##STR2## where R.sub.2 is hydrogen, lower alkyl and benzyl of the formula ##STR3## where X is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, nitro, and amino; ##STR4## where R.sub.3 and R.sub.4 are the same or different and are hydrogen and lower alkyl; ##STR5## where R.sub.5 and R.sub.6 are the same or different and are lower alkyl; and the pharmaceutically acceptable acid addition salts thereof.

REFERENCES:
patent: 4025640 (1977-05-01), McFadden et al.
Aultz et al., J. Med. Chem., vol. 20, (1977), pp. 66-70 and 456-458.
Yoshioka et al., J. Med. Chem., vol. 21, (1978), pp. 633-639.

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