Method of detecting and monitoring levels of 3'-amino-3'-deoxyth

Details Method of detecting and monitoring levels of 3'-amino-3'-deoxyth Method of detecting and monitoring levels of 3'-amino-3'-deoxyth

1993-09-07

1995-11-07

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 6, 435 71, 435 79, 435 792, 435 793, 435974, 436544, 436815, G01N 33531

Patent

active

054647487

ABSTRACT:
Immunoassay techniques for quantitating the amount of 3'-amido-3'-deoxythymidine (AMT) in body fluid samples, and antibodies useful in performing such immunoassays, are provided. The immunoassays use antibodies which are specific to AMT and have no cross-reactivity with 3'-azido-3'-deoxythymidine (AZT). Moreover, there is provided an improved method of conducting AZT therapy wherein the concentration of both AZT and AMT is monitored and the AZT dosage is adjusted to maintain rather low concentrations of AMT.

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