Deoxynucleic alkyl and alkoxy thiourea compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 231, 536 243, 536 2433, 536 245, C07H 2104, C07H 2102

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active

061369659

ABSTRACT:
The invention provides novel deoxynucleic alkyl thiourea (dNXt) oligonucleotide compounds for use in antisense or antigene therapy.

REFERENCES:
Branch, TIBS 23, p. 45-50, Feb. 1998.
Crooke "Antisense Research and Applications" p. 1-15, Jul. 7, 1998.
Bruice et al Proc. Natl. Acad. Sci vol. 92 pp. 7051-7055, Jul. 1995.
Agrawal, Sudhir et al., "Mixed-Backbone Oligonucleotides Containing Phophorothioate and Methylphosphonate Linkages as Second Generation Antisense Oligonucleotide," Nucleosides and Nuclesides and Nucleotides, 1997, 16(7-9):927-36. (Exhibit 1).
Alama, Angela et al., "Antisense Oligonucleotides as Therapeutic Agents," Pharmacological Research, 1997, 36(3):171-8. (Exhibit 3).
Blasko, Andrei et al., "Association of Short-Strand DNA Oligomers with Guanidinium-Linked Nucleosides. A Kinetic and Thermodynamic Study," Journal of the American Chemical Society, Aug. 28, 1996, 118(34):7892-9. (Exhibit 2).
Blasko, Andrei et al., "Fidelity of Binding of the Guanidinium Nucleic Acid (DNG) d(Tg).sub.4 -T-azido With Short Strand DNA Oligomers (A.sub.5 G.sub.3 A.sub.5, GA.sub.4 G.sub.3 A.sub.4 G, G.sub.2 A.sub.3 G.sub.3 A.sub.3 G.sub.2, G.sub.2 A.sub.2 G.sub.5 A.sub.2 G.sub.2). A Kinetic And Thermodynamic Study," Biochemistry, 1997, 36:7821-31. (Exhibit 4).
Blattler, Monika O. et al., "Distorting Duplex DNA by Dimethylenesulfone Substitution: A New Class of "Transition State Analog" Inhibitors for Restriction Enzymes," Journal of the American Chemical Society, Mar. 25, 1998, 120:2674-5. (Exhibit 5).
Bloodworth, A. J. et al., "1,1'-Thiocarbonyldi-2,2'-pyridone. A New Useful Reagent for Functional Group Conversions Under Essentially Neutral Conditions," The Journal of Organic Chemistry, Jun. 27, 1986, 51(13):2613-5. (Exhibit 6).
Browne, Kenneth A. et al, "Binding Studies of Cationic Thymidyl Deoxyribonucleic Guanidine to RNA Homopolynucleotides," Proc. Natl. Acad. Sci. USA, Jul. 1995, 92:1051-55. (Exhibit 7).
Crooke, Rosanne M., "In Vitro Toxicology and Pharmacokinetics of Antisense Oligonucleotides," Anti-Cancer Drugs Design, Nov. 1991, 6(5):609-46. (Exhibit 8).
Crooke, Stanley T. "Therapeutic Applications of Oligonucleotides," Annual Review of Pharmacology and Toxicology, 1992, 32:329-76. (Exhibit 9).
De Mesmaeker, Alain et al., "Amide Backbones with Conformationally Restricted Furanose Rings: Highly Improved Affinity of the Modified Oligonucleotides for Their RNA Complements," Angewandte Chemie, 1996,35(23/24):2790-4. (Exhibit 10).
De Mesmaeker, Alain et al., "Backbone Modifications for Antisense Oligonucleotides," Pure and Applied Chemistry, 1997, 69(3):437-40. (Exhibit 10).
De Mesmaeker, Alain et al., "Backbone Modifications in Oligonucleotides and Peptide Nucleic Acid Systems," Current Opinion in Structural Biology, 1995, 5(1):343-55. (Exhibit 12).
Dempcy, Robert O. et al., "Design and Synthesis of Deoxynucleic Guanidine: A Polycation Analogue of DNA (Antisense/Antigene/Hybrid Duplex/Triple Helix)," Proc. Natl. Acad. Sci. USA, Aug. 1994, 91:7864-8. (Exhibit 13).
Dempcy, Robert O. et al., "Design and Synthesis of Ribonucleic Guanidine: A Polycationic Analog of RNA (antisense/Antigene/Triple Helix)," Proc. Natl. Acad. Sci. USA, Apr. 1996, 93:4326-30. (Exhibit 14).
Dempcy, Robert O. et al., "Synthesis of a Thymidyl Pentamer of Deoxyribonucleic Guanidine and Binding Studies with DNA Homopolynucleotides (Antisense/Antigene/Hybrid Duplex/Triple Helix)," Proc. Natl. Acad. Sci USA, Jun. 1995, 92:6097-101. (Exhibit 15).
Dempcy, Robert O. et al., "Synthesis of the Polycation Thymidyl DNG, Its Fidelity in Binding Polyanionic DNA/RNA, and the Stability and Nature of the Hybrid Complexes," Journal of the American Chemical Society, Jun. 7, 1995, 117:6140-1. (Exhibit 16).
Egholm, Michael et al., "Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with an Achiral Peptide Backbone," Journal of American Chemical Society, Feb. 26, 1992, 114:1895-7. (Exhibit 17).
Fathi, Reza et al., "(Aminomethyl)Phosphonate Derivatives of Oligonucleotides," Bioconjugate Chemistry, 1994, 5:47-57. (Exhibit 18).
Gryaznov, Sergie and Jer-Kang Chen, "Oligodeoxyribonucleotide N3'.fwdarw.P5' Phosphoramidates: Synthesis and Hybridization Properties," Journal of American Chemical Society, Apr. 6, 1994, 116:3134-4. (Exhibit 19).
Iyer, Radhakrishnan P. et al., "Synthesis, Biophysical Properties, and Stability Studies of Mixed Backbone Oligonucleotides Containing Segments of Methylphosphotriester Internucleotidic Linkages," Tetrahedron, 1996, 52(46):14419-36. (Exhibit 20).
James, Kenneth D. et al., "Incorporation of 5'-N-BOC-2',5'-Dideoxynucleosided-3'-O-Phosphoramidites into Oligonucleotides by Automated Synthesis," Nucleosides and Nucleotides, 1997, 16(10-11):1821-36. (Exhibit 21).
Jones, Robert J. et al., "Synthesis and Binding Properties of Pyrimidine Oligodeoxynucleoside Analogs Containing Neutral Phosphodiester Replacements: The Formacetal and 3'-Thioformacetal Internucleoside Linkages," The Journal of Organic Chemistry, 1993, 58:2983-91. (Exhibit 22).
Jung, Paul M. et al., "Hybridization of Alternating Cationic/Anionic Oligonucleotides to RNA Segments," Nucleosides and Nucleotides, 1994, 13(6-7):1597-1607. (Exhibit 23).
Letsinger, Robert L. et al., "Cationic Oligonucleotides," Journal of the American Chemical Society, 1988, 110:4470-1. (Exhibit 24).
Marshall, W. S. and M. H. Caruthers, "Phosphorodithioate DNA as a Potential Therapeutic Drug," Science, Mar. 12, 1993, 259:1564-70. (Exhibit 25).
Miller, P. S. and P.O.P Ts'o, "A New Approach to Chemotherapy Based on Molecular Biology and Nucleic Acid Chemistry: Matagen (Masking Tape For Gene Expression)," Anti-Cancer Drug Design, Oct. 1987, 2(2):117-28. (Exhibit 26).
Milligan, John F. et al., "Current Concepts in Antisense Drug Design," Journal of Medicinal Chemistry, Jul. 9, 1993, 36(14):1923-37. (Exhibit 27).
Morvan, F. et al., "Comparative Evaluation of Seven Oligonucleotide Analogues as Potential Antisense Agents," Journal of Medicinal Chemistry, Jan. 22, 1993, 36(2):280-7. (Exhibit 28).
Nielsen, Peter E. and Gerald Haaima, "Peptide Nucleic Acid (PNA). A DNA Mimic with a Pseudopeptide Backbone," Chemical Society Reviews, 1997, 26(2):73-8. (Exhibit 29).
Peyman, Anusch et al., "Phosphonic Ester Nucleic Acids (PHONAs): Oligonucleotide Analogues with an Achiral Phosphonic Acid Ester Backbone," Angewandte Chemie, 1996, 35(22):2636:40. (Exhibit 30).
Rao, T. Sudhakar et al., "Synthesis of Triple Helix Forming Oligonucleotides With a Stretched Phosphodiester Backbone," Nucleosides and Nucleotides, 1994,131(1-3):255-73. (Exhibit 31).
Riley, Monica et al., "Physical and Chemical Characterization of Two- and Three-Stranded Adenine-Thymine and Adenine-Uracil Homopolymer Complexes," Journal of Molecular Biology, Sep. 1966, 20:359-389. (Exhibit 32).
Rougee, M. et al., "Kinetics and Thermodynamics of Triple-Helix Formation: Effects of Ionic Strength and Mismatches," Biochemistry, Sep. 29, 1992, 31(38):9296-78. (Exhibit 33).
Sanghvi, Yogesh S. et al., "Concept, Discovery and Development of MMI Linkage: Story of a Novel Linkage for Antisense Constructs," Nucleosides and Nucleotides, 1997, 16(7-9):907-16. (Exhibit 34).
Sood, Anup et al., "Boron-Containing Nucleic Acids: Synthesis of Cyanoborane Adducts of 2'-Deoxynucleosides," Journal of American Chemical Society, 1989, 111:9234-5. (Exhibit 35).
Spielvogel, Bernard F. et al., "From Boron Analogues of Amino Acids to Boronated DNA: Potential New Pharmaceuticals and Neutron Capture Agents," Pure and Applied Chemistry, 1991, 63(3):415-18. (Exhibit 36).
Stein, C. A. and Y.-C. Cheng, "Antisense Oligonucleotides as Therapeutic Agents--Is the Bullet Really Magical?," Science, Aug. 20, 1993, 261:1004-12. (Exhibit 37).
Stirchak, Eugene P. et al., "Uncharged Stereoregular Nucleic Acid Analogues. 1. Synthesis of a Cytosine-Containing Oligomer with Carbamate Internucleoside Linkages," The Journal of Organic Chemistry, 1987, 52:4202-6. (Exhibit 38).
Temsamani, Jamal and Philippe Guinot, "Antisense Oligonucleotides: A New Therapeutic Approach," Biological and Applied Biochemistry, Aug. 1997, 26(1):65-71. (Exhibit 39).
Thibon, Jacques et al., "Syn

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