Human SMT3-like protein

Details Human SMT3-like protein Human SMT3-like protein

1998-10-14

2000-10-24

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1400

Patent

active

061369551

ABSTRACT:
The present invention provides a human SMT3-like protein (HSMTH) and polynucleotides which identify and encode HSMTH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HSMTH and for treating or preventing disorders associated with expression of HSMTH.

REFERENCES:
Meeks-Wagner, D., et al., "Normal Stoichiometry of Histone Dimer Sets is Necessary for High Fidelity of Mitotic Chromosome Transmission," Cell, 44:43-52 (1986).
Meluh, P.B. (GI 881371; 881372) GenBank Sequence Database (Accession U27233) National Center for Biotechnology Information National Library of Medicine, Bethesda, Maryland, 20894.
Mannen, H., et al., "Cloning and Expression of Human Homolog HSMT3 to Yeast SMT3 Suppressor of MIF2 Mutations in a Centromere Protein Gene," Biochemical and Biophysical Research Communications, 222:178-180 (1996).
Lapenta, V., "SMT3A, a Human Homologue of the S. Cerevisiae SMT3 Gene, Maps to Chromosome 21qter and Defines a Novel Gene Family," Genomics, 40:362-366, (1997) (GI 170371; 170372).
Lapenta, V., (GI 170371; 170372) GenBank Sequence Database (Accession 170371; 170372) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Brown, M., et al., "MIF2 is Required for Mitotic Spindle Integrity during Anaphase Spindle Elongation in Saccharomyces cerevisiae," Journal of Cell Biology, 123:387-403 (1993).
Brown, M., "Sequence similarities between the yeast chromosome segregation protein Mif2 and the mammalian centromere protein CENP-C," Gene, 160:111-116 (1995).
Georgiou, G., "Optimizing the Production of Recombinant Proteins in Microorganisms", AIChE Journal, 34(8): 1233-1248 (1988).
Adams, M.D. et al. (GI 1957504) GenBank Sequence Database (Accession AA305177) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Adams, M.D. et al. (GI 389884) GenBank Sequence Database (Accession T08856) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
"PET-27B(+) Vetor", 1995, Novagen Catalog, p. 86 XP002029989.
Database Genbank, Accession No. AA305177, "EST176173, Homo Sapiens", XP002074683, compare nt 1-354 with nt 10364 of Seq. ID 1, Apr. 18, 1997.
Database Genbank, Accession No. T08856, Aug. 3, 1996, "EST06748, Homo sapiens.", XP002074684, compare nt 1-287 with nt 4-290 of Seq. ID 1.

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