Novel process for the preparation of N.sup.6 -alkyl-arprinocid

Details Novel process for the preparation of N.sup.6 -alkyl-arprinocid Novel process for the preparation of N.sup.6 -alkyl-arprinocid

1981-09-28

1982-11-30

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424253, C07D47334

Patent

active

043616992

ABSTRACT:
This invention is concerned with a novel process for the preparation of N.sup.6 -alkyl-arprinocid (6-alkyl-amino-9-substituted benzyl purines). Such compounds are active anticoccidial agents. The process involves the preparation of a Schiff base from an acetal of dialkylformamide and reduction with a metal hydride.

REFERENCES:
patent: 3846426 (1974-11-01), Lira et al.
patent: 4189485 (1980-02-01), Matsuno et al.
Meerwein et al., Ann. 641, 1, (1961).
Bredereck et al., Angew. Chem., 73, 493, (1961).
Neilson, Chemistry of Amidines and Imidates, Patai Ed., pp. 385-413, (1975).
Imai et al., European J. Med. Chems., 15, 207-210, (1980).

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