Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-04-07
2000-10-24
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514730, 514784, 514311, 514314, 514422, 514428, 514444, 514461, 546152, 546174, 548517, 548526, 549 60, 549368, 549472, 549473, A61K 31335, A61K 31357, A61P 3306, C07D32306
Patent
active
061368474
ABSTRACT:
Biologically-active, water soluble, 3-substituted trioxanes of the formula ##STR1## wherein R represents a COOH-- substituted aryl group, a substituted or unsubstituted heteroaryl group or an alkyl group, and C.sub.12 -(p-carboxy)benzyloxy trioxanes of formula ##STR2## wherein R represents a substituted or unsubstituted alkyl, alkenyl, aryl or heteroaryl group and methods for their use as antiparasitic agents, particularly for the treatment of malaria.
REFERENCES:
Posner et al., "Synthesis and antimalarial activities of structurally simplified 1,2,4-trioxanes related to artemisinin," Heteroat. Chem., 6(2), pp. 105-116 (Abstract), 1995.
Posner et al., "Evidence for the Importance of High Valent Fe=O and of a Diketone in the Molecular Mechanism of Action of Antimalarial Trioxane Analogs of Artemisinin," J.Am.Chem.Soc., vol. 118, pp. 3537-3538, Apr. 10, 1996.
Krasavin Mikhail
Parker Michael H.
Posner Gary H.
Shapiro Theresa A.
Johns Hopkins University
McKane Joseph
Oswecki Jane C.
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