Stock material or miscellaneous articles – Coated or structually defined flake – particle – cell – strand,... – Particulate matter
Patent
1993-07-26
1995-11-07
Nakarani, D. S.
Stock material or miscellaneous articles
Coated or structually defined flake, particle, cell, strand,...
Particulate matter
1286532, 1286534, 428407, 436173, 436525, 436526, B23B 516
Patent
active
054646960
ABSTRACT:
Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.
REFERENCES:
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patent: 4951675 (1990-08-01), Groman et al.
patent: 5160725 (1992-11-01), Pilgrimm
patent: 5246707 (1993-09-01), Heynes
patent: 5262176 (1993-11-01), Palmacci et al.
Grant & Hackt's Chemical Dictionary. 5th Edition, p. 445.
R. H. Miller et al., "In Vitro characterization of . . . " Journal of Controlled Release 20 (1992) Aug. No. 3, Amsterdam NL, pp. 237-246.
Database WPIL Week 9241, Derwent Publication Ltd., London, GB, AN 92-337723 & JP-A-4 244 017 (Kyowa Hakko Kogyo) 1. Abstract. Sep. 1992.
Hyacinthe Roland
Schneider Michel
Tournier Herve
Bracco International B.V.
Le H. T.
Nakarani D. S.
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