Method of inactivating lipid-enveloped viruses

Details Method of inactivating lipid-enveloped viruses Method of inactivating lipid-enveloped viruses

1998-02-10

2000-10-24

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241841, 4352351, 435236, 435238, 435239, A61K 3912, C12N 706

Patent

active

061363219

ABSTRACT:
The invention relates to a method of inactivating lipid-enveloped viruses by means of a non-ionic detergent, and the preparation of a vaccine containing the inactivated virus. The invention further relates to an inactivated virus which is characterized by its structural integrity, in particular the structural integrity of its enveloping proteins, as well as to the use of the inactivated virus for preparing a vaccine.

REFERENCES:
Haraud, "Introductory Remarks: Viral Safety Of Biologicals", Develop. Biol. Standard, vol. 75:3-7, (1991).
Brown, "Review Of Accidents Caused By Incomplete Inactivation Of Viruses", Develop. Biol. Standard, vol. 81:103-107, (1993).
Smith et al., "Laboratory Aspects Of Fourteen Human Cases Following Vaccination And Attempts To Isolate The Virus From The Vaccine", Am. J. Hyg., vol. 63:150-164, (1956).
Mussgay et al., "Preparation Of Inactivated Vaccines Against Alphaviruses Using Semliki Forest Virus--White Mouse As A Model", Intervirology, vol. 1:259-268, (1973).
Piet et al., "The Use Of Tri(n-butyl)phosphate Detergent Mixtures To Inactivated Hepatitis Viruses And Human Immunodeficiency Virus In Plasma And Plasma's Subsequent Fractionation", Transfusion, vol. 30(7):591-598, (1990).
Danihelkova et al., "Disruption Of Influenza Virus A By Diethylether-tween and Tri-N-Butyl Phosphate-tween Mixtures", Acta Virol., vol. 28:26-32, (1984).
Gross et al., "Comparison Of New Triton X-100-and Tween-Ether-Treated Split-Product Vaccines In Children", Journal Of Clinical Microbiology, vol. 14(5):534-538, (1981).
Hennig et al., "Immunization with Tween-Ether-Treated SIV Adsorbed Onto Aluminum Hydroxide Protects Monkeys Against Experimental SIV Infection", Virology, vol. 186:588-596, (1992).
Reed et al., "A Simple Method Of Estimating fifty Per Cent Endpoints", The Journal of Hygiene, vol. 27(3):493-497, (1938).
Laemmli, "Cleavage Of Structural proteins During The Assembly Of The head of Bacteriophage T4", Nature, vol. 277:680-685, (1970).

Affiliated with

Also associated with

Rating

Method of inactivating lipid-enveloped viruses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of inactivating lipid-enveloped viruses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inactivating lipid-enveloped viruses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1960654