Recombinant anti-CD4 antibodies for human therapy

Details Recombinant anti-CD4 antibodies for human therapy Recombinant anti-CD4 antibodies for human therapy

1995-09-06

2000-10-24

Bansal, Geetha P.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

5303873, 4241331, 4241411, A61K 39395, C12P 2108

Patent

active

061363103

ABSTRACT:
Chimeric antibodies specific to human CD4 antigen, DNA encoding, pharmaceutical compositions containing and use thereof as therapeutic agents are taught. These chimeric antibodies contain Old World monkey variable sequences and human constant domain sequences, preferably human gamma 1, gamma 4 or mutated forms thereof. These antibodies possess desirable therapeutic properties including low antigenicity, reduced (or absent) T cell depleting activity, good affinity to human CD4 and enhanced stability (in vivo half-life).

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