Use of CD4-binding small molecules to inhibit immune responses

Details Use of CD4-binding small molecules to inhibit immune responses Use of CD4-binding small molecules to inhibit immune responses

1997-12-09

2000-10-03

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514339, 514355, 514366, 514383, 514825, 514885, 514903, A61K 31425

Patent

active

061273872

ABSTRACT:
The application concerns a method of identifying compounds that can be used to inhibit undesired human CD4.sup.+ T cell immune responses by identifying compounds that block the interaction of CD4 and class II MHC gene products and a method of treatment which comprises administering such an identified compound. The compounds that inhibit undesired human CD4.sup.+ T cell immune responses can be used to treat disease such as multiple sclerosis and to prevent graft rejection and graft versus host disease. More specifically, the application concerns compounds having molecular weights between about 500 and 150 that bind to the GFCC'C" portion of the D1 domain of human CD4 lymphocyte cell surface antigen.

REFERENCES:
patent: 4497817 (1985-02-01), Murase et al.
patent: 4882336 (1989-11-01), Tigyi et al.
Acha-Orbea et al., 1988, Cell 54:263-273.
Anderson et al., 1987, J. Immunol. 139:678-682.
Barber et al., 1989, Proc. Natl. Acad. Sci. 86:3277-3281.
Ben-Nun et al., 1981, Eur. J. Immunol. 11:195-199.
Bernard et al., 1975, J. Immunol. 114:1537-1540.
Chou et al., 1983, J. Immunol. 130:2183-2186.
Clayton et al., 1989, Nature 339:540-51.
Davis et al., 1990, J. Biol. Chem. 265:10410-10418.
Dianzani et al., 1990, Eur. J. Immunol. 20:2249-2257.
Doyle et al., 1987, Nature 330:256-259.
Emmrich et al., 1987, Eur. J. Immunol. 17:529-534.
Gay et al., 1987, Nature 328:626-629.
Hafler et al., 1988, J. Immunol. 141:131-138.
Hafler et al., 1989, Immunology Today 10:104-107.
Jameson et al., 1994, Nature 368:744-746.
Janeway 1991, Seminars in Immunology 3:153-160.
June et al., 1990, J. Immunol. 144:1591-1599.
Korngold et al, 1986, Immunogenetics 24:309-315.
Kuchroo et al., 1992, J. Immunol. 148:3776-3782.
Langedijik et al., 1993, J. Biol. Chem. 268:16875-16868.
Lee et al., 1971, J. Mol. Biol. 55:379-400.
Lindsly et al., 1994, Annals of Neurology 36:183-189.
MacRae et al., 1995, J. Neuroimmunol. 60:17-28.
Martin et al., 1992, Ann. Rev. Immunol. 10:153-187.
Meng et al, 1992, J. Comput. Chem. 13:505-525.
Miceli et al., 1993, adv. Immunol. 53:59-121.
Moebius et al., 1992, Proc. Natl. Acad. Sci. 89:12008-12012.
Moebius et al., 1993, Proc. Natl. Acad. Sci. 90:8259-8263.
Mosier et al., 1988, Nature 335;256-259.
Peters et al., 1996, J. Mol. Biol. 256:201-213.
Pettineli et al., 1981, J. Immunol. 127:1420-1421.
Racadot et al., 1993, J. Autoimmunity 6:771-786.
Raine et al., 1991, Neuropath. appl. Neurobiol. 17:265-274.
Raine et al., 1988, J. Neuroimmunol. 20:189-201.
Ring et al., 1993, Proc. Natl. Acad. Sci, 90:3583-3587.
Rivas, 1988, J. Immunol. 140:2912-2918.
Saizawa et al., 1987, Nature 328:260-263.
Sakihama et al, 1995, Proc. Natl. Acad. Sci. 92:6444-6448.
Satoh et al, 1996, Biochem. Biophys. Res. Com. 224:438-443.
Steinman et al., 1993, Proc. Natl. Acad. Sci. USA 78:7111-7114.
Teh, et al., 1991, Nature 349:241-243.
Traugott et al., 1985, Cellular Immunology 91:240-254.
Turner et al., 1990, Cell 60:755-765.
Veillette et al., 1988, Cell 55:301-308.
Waldor et al, 1985, Science 227:415-417.
Weber et al., 1993, Int. Immunol. 5:695-698.
White et al., 1978, J. Exp. Med. 148:664-673.
Wraith et al., 1989, Cell 59:247-255.
Zhang et al., 1996, Nature Biotechnology, 14:472-475.

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