Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-13
1998-05-26
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5462827, 5462831, A61K 3144, C07D40104, C07D40500
Patent
active
057565210
ABSTRACT:
Compounds of the formula: ##STR1## in which n is one of the integers 1, 2, 3 or 4, or a pharmaceutically acceptable salt thereof, are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analogous drugs.
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Kerrigan et al, "Preparation of Aromatic Bicycle heterocyclic compounds as serotoninergic and dopaminergic receptor antogonists" CA123:340154 (1995).
Boettcher et al, "Preparation of arylaminesas central nervous system agents", CA125:58325, (1996).
Corsini et al., Adv. Biochem. Psychopharmacol, 16, 645-648, 1977.
Lahti et al., Mol. Pharm. 42, 432-438, 1993.
Tamminga et al., Science, 200, 567-568, 1978.
Tamminga et al., Psychiatry, 398-402, 1986.
American Home Products Corporation
Barrett Rebecca R.
Lambkin Deborah C.
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