Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-03
1998-05-26
Seidleck, James J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A01N 4390
Patent
active
057565112
ABSTRACT:
A method for treating symptoms of Alzheimer's Disease by administering an effective amount of a compound, racemate, isolated R or S enantionmer, solvate, hydrate or salt having the formula:
REFERENCES:
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Ashall et al., TEBS, vol. 19, 1994, pp. 42-46, "Role of the .beta.-amyloid Precursor Protein in Alzheimer's Disease".
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Kosik, Science, vol. 256, 1992, pp. 780-783, "Alzheimer's Disease: A Cell Biological Perspective".
Attardi et al., Cold Spring Harbor Symposia on Quantitative Biology, vol. L1, 1986, pp. 103-114, Seven Unidentified Reading Frames of Human Mitochondrial DNA Encode Subunits of the Respiratory Chain NADH Dehydrogenase.
Flier, Jeffrey; ".beta.-Amyloid and the Pathogenesis of Alzheimer's Disease" Sem. Med. vol. 325 No. 26 p. 1849.
Behl, C. "Hydrogen Peroxide Mediates Amyloid .beta. Protein Toxicity" Cell. vol. 77 pp. 817-827, Jun. 17, 1994.
Ashall, Frank et al; "Role of the .beta.-Amyloid Precursor Protein in Alzheimer's Disease, " TIBS 19, Jan. 1994 pp. 42-47.
Hardy, John et al; Alzheimer's Disease: The Amyloid Cascade Hypothesis; (Perspective) Science, vol. 256 pp. 184-185 (1992).
Kosik, Kenneth S. "Alzheimer's Disease: A Cell Biological Perspective" Science, vol. 256 (1992) pp. 780-783.
Attardi G, "Seven Unidentified Reading Frames of Human Mitrochondrial DNA Encode Subunits of the Respiratory Chain NADH Dehydrogenase." vol. LI., (1986) pp. 103-114.
Klein J. Peter
Kumar Anil M.
Leung David W.
Underiner Gail E.
West James W.
Cell Therapeutics Inc.
Faciszewski Stephen
Mosley Terressa
Seidleck James J.
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