Intraocular irrigating and enucleated eyeball preservative compo

Details Intraocular irrigating and enucleated eyeball preservative compo Intraocular irrigating and enucleated eyeball preservative compo

1994-02-16

1996-03-19

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514912, A61K 3134

Patent

active

055004458

ABSTRACT:
This invention relates to an intraocular irrigating and enucleated eyeball preservative composition containing a phosphoric acid diester compound of the following formula or a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group.
The composition of this invention is highly lenient to the ocular tissues, particularly in the sense that it protects the corneal (endothelial) cells which are most susceptible to physiological damage in ophthalmic surgery, with the result that various ophthalmic operations can be carried out with sufficient safety. Furthermore, since the composition of this invention may help retain the physiological functions of the enucleated eyeball without injuring its tissues, it can be used with advantage for the preservation of the cornea, retina, crystalline lens and so on.

REFERENCES:
patent: 5194445 (1993-03-01), Satoh et al.
The Merck Index, Eleventh Edition, 1989, pp. 130-131.
Chemical Abstracts 111:45280t (1989). Senoo et al.

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