Pyrimidine and pyridine derivatives, their production and use

Details Pyrimidine and pyridine derivatives, their production and use Pyrimidine and pyridine derivatives, their production and use

1994-08-12

1996-03-19

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142278, 5142358, 514252, 514269, 514273, 514274, 514318, 514332, 514343, 514349, 544 60, 544121, 544122, 544129, 544130, 544295, 544316, 544322, 544357, 544360, 544372, 546194, 546281, 546290, 546306, 546309, A61K 31535, A61K 3154, A61K 31495, A61K 31505, A61K 3144, C07D41700, C07D41300, C07D40300, C07D21302, C07D40100, C07D21172

Patent

active

055004245

ABSTRACT:
The present invention relates to a compound represented by the general formula (I): ##STR1## [wherein R.sup.1 is a lower alkyl group or the like, R.sup.2 is a lower alkyl group or the like, R.sup.3 and R.sup.4, which may be the same or different, are halogen atoms or the like, R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, are halogen atoms or the like, and X is .dbd.N-- or .dbd.CH--] or a pharmacologically acceptable salt thereof, which has inhibitory effect on acyl-CoA:cholesterol O-acyltransferase (ACAT), a process for producing said compound, and uses of said compound.

REFERENCES:
patent: 4716175 (1987-12-01), Hoefle et al.
patent: 4722927 (1988-02-01), Holmes
patent: 4994465 (1991-02-01), Trivedi
patent: 5185358 (1993-02-01), Creswell et al.

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