Process for leukotriene antagonists

Details Process for leukotriene antagonists Process for leukotriene antagonists

1988-01-11

1988-10-11

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 4500

Patent

active

047772999

ABSTRACT:
1,3-Dialkylbenzenes are acylated and deprotected in a mixture of acetic or propionic acid and hydrobromic acid. The dihydroxyphenones thus produced are intermediates in the synthesis of leukotriene antagonists.

REFERENCES:
patent: 4661505 (1987-04-01), Marshall et al.
P. Da Re and L. Cimatoribus, Journal of Organic Chemistry, 26, pp. 3650-3653 (1961).
G. P. Schiemenz and U. Schmidt, Liebigs Annalen der Chemie, pp. 1514-1519 (1976).
J. March, Advanced Organic Chemistry-Reactions, Mechanism, and Structure, Second Edition, McGraw-Hill Book Company, New York, pp. 394-395 (1977).

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