Glycyl tRNA synthetase polynucleotides of streptococcus

Details Glycyl tRNA synthetase polynucleotides of streptococcus Glycyl tRNA synthetase polynucleotides of streptococcus

1997-04-18

1998-05-26

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 4352523, 43525411, 435325, 4353201, 536 232, 536 243, C12N 900, C12N 1500, C12N 120, C07H 2104

Patent

active

057563306

ABSTRACT:
The invention provides glyS (beta) and glyS (alpha) polypeptides and DNA (RNA) encoding glyS (beta) and glyS (alpha) polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glyS (beta) and glyS (alpha) polypeptides to screen for antibacterial compounds.

REFERENCES:
Niyomporn et al. (1968) Biosynthesis of the Peptidoglycan of Bacterial Cell Walls. J. Biol. Chem. 243(4): 773-778.
Webster et al., "Primary Structures of Both Subunits of Escherichia coli Glycyl-tRNA Synthetase," Journal of Biological Chemistry, 258(17) pp. 10637-10641 (1983).
Fleischmann et al., "Whole-Genome Random Sequencing and Assembly of Haemophilius influenzae Rd.," Science, 269 pp. 496-512 (1995).
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escherichia coli and Bacillus subtilis", Biochemistry, 5(5) pp. 1681-1690 (1966).
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).

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