Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1996-12-02
2000-10-24
Lateef, Marvin M.
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600408, 128925, A61B 600
Patent
active
061359653
ABSTRACT:
An apparatus and methods for spectroscopic detection of tissue abnormality, particularly precancerous cervical tissue, using neural networks to analyze in vivo measurements of fluorescence spectra. The invention excites fluorescence intensity spectra in both normal and abnormal tissue. This fluorescence spectroscopy data is used to train a group (ensemble) of neural networks, preferably radial basis function (RBF) neural networks. Once trained, fluorescence spectroscopy data from unknown tissue samples is classified by the trained neural networks. This process is used to differentiate pre-cancers from normal tissues, and can also be used to differentiate high grade pre-cancers from low grade pre-cancers. One embodiment of the invention is able to distinguish pre-cancerous tissue from both normal squamous tissue (NS) and normal columnar (NC) tissue in a single-stage of analysis. The invention demonstrates significantly smaller variability in classification accuracy, resulting in more reliable classification, with superior sensitivity. Moreover, the single-stage embodiment of the invention simplifies the decision-making process as compared to a two-stage embodiment.
REFERENCES:
patent: Re30712 (1981-08-01), Macemon
patent: 3647299 (1972-03-01), Lavallee
patent: 3789832 (1974-02-01), Damadian
patent: 4037961 (1977-07-01), Macemon
patent: 4170987 (1979-10-01), Anselmo et al.
patent: 4213462 (1980-07-01), Sato
patent: 4479499 (1984-10-01), Alfano
patent: 4569354 (1986-02-01), Shapiro et al.
patent: 4637400 (1987-01-01), Marcus
patent: 4718417 (1988-01-01), Kittrell et al.
patent: 4930516 (1990-06-01), Alafano et al.
patent: 5125404 (1992-06-01), Kittrell et al.
patent: 5201318 (1993-04-01), Rava et al.
patent: 5301681 (1994-04-01), DeBan et al.
patent: 5331550 (1994-07-01), Stafford et al.
patent: 5345941 (1994-09-01), Rava et al.
patent: 5421337 (1995-06-01), Richards-Kortum et al.
patent: 5421339 (1995-06-01), Ramanujam et al.
patent: 5450527 (1995-09-01), Wang
patent: 5485530 (1996-01-01), Lakowicz et al.
patent: 5486999 (1996-01-01), Mebane
patent: 5528046 (1996-06-01), Ishikawa
patent: 5528368 (1996-06-01), Lewis et al.
patent: 5539517 (1996-07-01), Cabib et al.
patent: 5544650 (1996-08-01), Boon et al.
patent: 5596992 (1997-01-01), Haaland et al.
patent: 5599717 (1997-02-01), Vo-Dinh
patent: 5612540 (1997-03-01), Richards-Kortum et al.
patent: 5623932 (1997-04-01), Ramanumjam et al
patent: 5657362 (1997-08-01), Giger et al.
patent: 5660181 (1997-08-01), Ho et al.
patent: 5664574 (1997-09-01), Chance
patent: 5669795 (1997-09-01), Richards-Kortum et al.
patent: 5687716 (1997-11-01), Kaufmann et al.
patent: 5697373 (1997-12-01), Richards-Kortum et al.
patent: 5701902 (1997-12-01), Vari et al.
patent: 5741648 (1998-04-01), Hemstreet, III et al.
patent: 5784162 (1998-07-01), Cabib et al.
Ghosh Joydeep
Ramanujam Nirmala
Richards-Kortum Rebecca
Tumer Kagan
Board of Regents , The University of Texas System
Lateef Marvin M.
Shaw Shawna J.
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