Refolding variant of bone morphogenetic protein-8

Details Refolding variant of bone morphogenetic protein-8 Refolding variant of bone morphogenetic protein-8

1994-12-21

1998-05-26

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 530333, 530399, C07K 1451, C12N 1512

Patent

active

057563080

ABSTRACT:
DNA molecules encoding mutant forms of bone morphogenetic proteins (BMP) are disclosed. The mutant forms of BMP can be produced bacterially and refolded to produce biologically active homodimers or heterodimers of BMP. A method of making such mutant BMPs is also disclosed.

REFERENCES:
patent: 5013649 (1991-05-01), Wang et al.
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5187076 (1993-02-01), Wozney et al.
King, "Genetic Analysis of Protein Folding Pathways" Bio/Technology 4:297-303 (Apr. 1986).
Ozkaynak et al, "Osteogenic Protein-2" J. Biol. Chem. 267(35):25220-25227 (Dec. 1992).
Kohno, Meth. Enzym. 185:187-195 (1990).
Taniguchi et al., PNAS USA 77:5230-5233 (1980).
Thies et al., J. Bone and Mineral Res. 5(2):305 (1990).
Thies et al., Endocrinology 130:1318-1324 (1992).
Sampath and Reddi, PNAS USA 80:6591-6595 (1983).
Norrander et al., Gene 26:101-106 (1983).
Sanger et al., J. Mol. Biol. 162:729-773 (1982).
Takagi et al., Nucl. Acids. Res. 13:2063-2074 (1985).
Dagert and Ehrlich, Gene 6:23 (1979).
Tandon and Horowitz, J. Biol. Chem., 262:4486-4491 (1987).

Affiliated with

Also associated with

Rating

Refolding variant of bone morphogenetic protein-8 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Refolding variant of bone morphogenetic protein-8, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Refolding variant of bone morphogenetic protein-8 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1958951