Process for producing a-hydroxy acid or a-hydroxyamide by microo

Details Process for producing a-hydroxy acid or a-hydroxyamide by microo Process for producing a-hydroxy acid or a-hydroxyamide by microo

1996-11-08

1998-05-26

Richter, Johann

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

435129, 435132, 435155, 558303, 558451, 564473, 564490, 568700, 568704, 568880, 562531, 423364, C12P 104, C12P 742, C07C 2914, C07C 5108

Patent

active

057563063

ABSTRACT:
A process for producing an .alpha.-hydroxy acid or an .alpha.-hydroxyamide which comprises treating an aldehyde and prussic acid or an .alpha.-hydroxynitrile with a microorganism having nitrilase or nitrile hydratase activity in an aqueous medium and maintaining the aldehyde concentration and/or the .alpha.-hydroxynitrile concentration in the reaction mixture within a predetermined range. Also disclosed is a process for producing an .alpha.-hydroxy acid or an .alpha.-hydroxyamide from an aldehyde and prussic acid with a microorganism in an aqueous medium, which comprises maintaining the cyanogen concentration in the reaction mixture within a predetermined range and supplying the aldehyde to the reaction mixture at a predetermined ratio to the prussic acid.

REFERENCES:
patent: 5326702 (1994-07-01), Endo et al.

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