Substituted benzothiazoles, benzimidazoles, and benzoxazoles

Details Substituted benzothiazoles, benzimidazoles, and benzoxazoles Substituted benzothiazoles, benzimidazoles, and benzoxazoles

1985-09-20

1989-10-10

Ceperley, Mary E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548159, 548160, 548161, 548165, 548169, 548170, 548173, 548221, 548222, 548327, 548328, 548329, C07D41712, C07D27774

Patent

active

048733466

ABSTRACT:
The present invention provides certain novel substituted benzothiazoles, benzimidazoles and benzoxazoles which are useful as inhibitors of leukotriene biosynthesis and/or as inhibitors of the action of lipoxygenase and/or as inhibitors of mucus secretion in mammalian metabolism. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.

REFERENCES:
patent: 2769010 (1956-10-01), D'Amico
patent: 3704239 (1972-11-01), Webe
patent: 3715363 (1973-02-01), Diekman
patent: 3775426 (1973-11-01), Wei et al.
patent: 3849431 (1974-11-01), Gallay et al.
patent: 3934017 (1976-01-01), Gallay et al.
patent: 3985762 (1976-10-01), Dransch et al.
patent: 4216160 (1980-08-01), Dorn et al.
patent: 4294839 (1981-10-01), Doll et al.
patent: 4328219 (1982-05-01), Mues et al.
patent: 4329363 (1982-05-01), Dorn et al.
patent: 4340738 (1982-07-01), Sipido
patent: 4612049 (1986-09-01), Berner et al.
patent: 4696763 (1987-09-01), Bentley et al.
patent: 4719036 (1988-01-01), Clubley et al.
R. A. Glennon et al., Benz-Fused Mesoionic Xanthine Analogues as Inhibitors of Cyclic-AMP Phosphodiesterase, J. Med. Chem. 24: 766-69 (1981).
P. T. S. Lau and T. E. Gompft, Reaction of Quinones with Thiourea, J. Org. Chem. 35:4103-08 (1970).
G. Foscolos et al., (not translated), Prakt. Akad. Athenon 51:274-91 (1976).
K. Tanaka et al., Cyclization of [(4- or 5-Substituted-2-Benzimidazolyl)thio]Acetic Acids, Chem. Pharm. Bull. 29:1876-86 (1981).
H. O. Hankovszky et al., Benzazoles, V., The Preparation of 2-(N-Arylideneamino)benzazoles and 2-(N-Arylideneneaminomethyl)benzimidazoles and Their Reduction with Sodium Borohydride, Acta Chimica Academiae Scientiarum Hungaricae Tomus 53:405-16 (1967).
M. Patra et al., J. Indian Chem. Soc., vol. LV, Jun. 1978, pp. 587-588.
J. D'Amico et al., J. Am. Chem. Soc. 81, 5957-63 (1959).

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