Immediate release tablet cores of insoluble drugs having sustain

Details Immediate release tablet cores of insoluble drugs having sustain Immediate release tablet cores of insoluble drugs having sustain

1993-11-23

1996-03-19

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424479, 424480, 424481, 424482, 424468, A61K 932, A61K 934, A61K 936, A61K 942

Patent

active

055002277

ABSTRACT:
A controlled release tablet for oral administration is disclosed which has a tablet core including an insoluble therapeutically active agent having an aqueous solubility of less than or equal to about 5 mg/ml in a sufficient amount to render a therapeutic effect. The core provides rapid release of said therapeutically active agent upon exposure to aqueous solutions. The tablet core is coated with a controlled release coating permitting sustained release of said therapeutically active agent when said coated tablet is exposed to aqueous solutions.

REFERENCES:
patent: 4752470 (1988-06-01), Mehta
patent: 4840799 (1989-06-01), Appelgren et al.
patent: 4892741 (1990-01-01), Ohm et al.
patent: 5122384 (1992-06-01), Paradissis et al.
patent: 5133974 (1992-07-01), Paradissis et al.

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