Derivatives of paraherquamide isolated from a fermentation broth

Details Derivatives of paraherquamide isolated from a fermentation broth Derivatives of paraherquamide isolated from a fermentation broth

1987-11-27

1989-10-10

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544230, A61K 31495, C07D49122

Patent

active

048732478

ABSTRACT:
Paraherquamide is a fungal metabolite isolated from the known fungus Penicillium paraherquei, and from a newly isolated strain of the fungus Penicillium charlesii. Additional compounds are disclosed which are related to paraherquamide and have been isolated from Penicillium charlesii. The compounds are potent antiparasitic agents. Compositions including such compounds as the active ingredient thereof for antiparasitic uses against endo and ecto parasites are also disclosed, as well as process for the preparation of such compounds from the newly isolated fungus.

REFERENCES:
Yamazaki et al., "Struct. Paraherquamide", Tetrahed. Lett., 22, pp. 135-136 (1981).
Attachment, MPEP 608.01 (P) Subject C, "Suggestion for Deposit of Biological Material".

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