Difluoro peptide compounds

Details Difluoro peptide compounds Difluoro peptide compounds

1987-05-19

1989-10-10

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, A61K 3743, C07K 508

Patent

active

048732214

ABSTRACT:
The invention relates to selected difluoro compounds of formulae Ia, Ib and Ic ( set out hereinafter) which are useful as inhibitors of human leukocyte elastase.

REFERENCES:
Buehler et al., "Organic Syntheses", (1974), pp. 625 & 626.
Wagner et al., "Synthetic Organic Chemistry", (1953), pp. 303 & 324.
Jounral of Medicinal Chemistry 28, noll., (1985), 1553-1555.
J. Med. Chem., (1986), 2080-7, vol. 29.
Biochemistry, 24 (1985), 1813-1817.

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