Process for the preparation of insulin, analogs and derivatives

Details Process for the preparation of insulin, analogs and derivatives Process for the preparation of insulin, analogs and derivatives

1975-08-14

1977-03-22

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

A61K 3726, C07C10352

Patent

active

040136280

ABSTRACT:
A process for the manufacture of insulin and derivatives thereof by treating an insulin derivative, wherein the A-chain is cross-linked with the B-chain by means of a sulfonyl diethyl-bisoxycarbonyl bridge and the B-chain may contain an acyl group in the 1-position, with alkali metal hydroxides or quaternary organic bases having a pH value of more than 13.

REFERENCES:
patent: 3883496 (1975-05-01), Geiger
patent: 3883500 (1975-05-01), Geiger et al.
patent: 3884897 (1975-05-01), Geiger et al.
patent: 3907763 (1975-09-01), Brandenburg et al.

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