Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-04-01
2000-10-03
Weber, Jon P.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 15, 514 16, 530326, 530327, 530329, A61K 3804, A61K 3806, A61K 3810, C07K 706, C07K 708
Patent
active
061273384
ABSTRACT:
A water soluble extract of M.charantia named MC6, methods for its preparation and methods for its use in the treatment of hyperglycemic disorders are provided. The active MC6 is characterized by moving as a single band on SDS-PAGE having a molecular weight of less than 10 kDal, and by comprising three peptides. Also provided is a peptide component of MC6 named MC6.1, as well as analogues and mimetics thereof. The active MC6, MC6.1, MC6.2, and MC6.3 exhibit hypoglycemic activity, even following oral administration. Also provided are methods of using the active agents to treat hyperglycemic disorders, particularly diabetes, where the active agents are preferably orally administered.
REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3853914 (1974-12-01), Goldstein et al.
patent: 3905654 (1975-09-01), Tribe
patent: 3945988 (1976-03-01), Khannet et al.
patent: 4043989 (1977-08-01), Schneider et al.
patent: 4069105 (1978-01-01), Singh et al.
patent: 4156081 (1979-05-01), Singh et al.
patent: 4368149 (1983-01-01), Masuho et al.
patent: 4985248 (1991-01-01), Liu
patent: 5086043 (1992-02-01), Liu
patent: 5098710 (1992-03-01), Liu
Stahl et al. Biochem. (1993) 32: 1991-2002.
Rudinger "Peptide Hormones," Parsons J.A., editor. (1976) (University park press: Baltimore, MD) p. 1-7.
Akhtar et al., (1981) "Effect of Momordica charantia on Blood Glucose Level of Normal and Alloxan-diabetic Rabbits," Planta Med. 42: 205-212.
Ali et al., (1993) "Studies on Hypoglycemic Effects of Fruit Pulp, Seed, and Whole Plant of Momordica charantia on Normal and Diabetic Model Rats," Planta Med. 59: 408-412.
Aslam et al. (1979) "Interaction Between curry Incredient (Karela) and Drug (Chlorpropamide)" Lancet I:607.
Baldwa et al. (1977) "Clinical Trial in Patients with Diabetes Mellitus of an Insulin-like Compound Obtained from Plant Source," Upsala J. Med. Sci. 82:39-41.
Di Colo (1992) "Controlled drug release from implantable matrices based on hydrophobic polymers," Biomaterials 13: 850-856.
Driscoll et al. (1993) "Two-dimensional Nuclear Magnetic Resonance Analysis of a Labeled Peptide Bound to a Class II Major Histocompatibility Complex Molecule," J. Mol. Bio. 232:342-350.
Dubey, D.K., et al. (1987) "Hypoglycaemic and Antihyperglycaemic Effects of Momordica Charantia Seed Extracts in Albino Rats," Fitoterapia 58(6):387-39.
El-Gengaihi, S., et al. (1996) "Chemical and Biological Investigation of Polypeptides of Momordica and Luffa Spp. Fam. Cucurbitaceae," Bull. Natl. Res. Cent. (Egypt) 21(3):269-276.
Hales & Randle, (1963) "Immunoassay of Insulin with Insulin-Antibody Precipitate," Biochem. J. 88:137.
Harrison's "Principles of Internal Medicine", 11th ed., Braunwald et al. ed., McGraw Hill Book Co. NY 1987.
Heller, "Biodegradable Polymers in Controlled Drug Delivery," CRC Critical Reviews in Therapeutic Drug Carrier Systems, vol. 1, CRC Press, Boca Raton, FL 1987, pp. 39-90.
Kadish et al. (1968) "A New and Rapid Method for the Determination of Glucose by Measuraement of Rate of Oxygen Consumption," Clin. Chem. 14: 116.
Karunanayake, E.H., et al. (1984) "Oral Hypoglycaemic Activity of Some Medicinal Plants of SRI Lanka," J. Ethnopharmacol. 11(2):223-232.
Khanna, P., et al. (1979) "A Hypoglycemic Polypeptide From Vegetable Source with an Alternate Mode of Action," J. Natural Products 42(6):684.
Khanna et al. "Hypoglycemic Activity of Polypeptide-p from a Plant Source," 20th Annual Meeting of the American Society of Pharmacoloby, Purdue University, West Lafayette, Jul. 29-Aug. 3, 1979.
Ng,Ph.D. et al., "Acid-Ethanol Extractable Compounds from Fruits and Seeds of the Bitter Gourd Momordica Charantia: Effects on Lipid Metabolism in Isolated Rat Adipocytes," The American J. of Chinese Medicine, vol. 15, No. 1-2, 31-42, 1987.
Lei, Q., et al. (1985) "Influence of Balsam Pear (The Fruit of Momordica Charanti a L.) On Blood Sugar Level." J. Tradit. Chin. Med. 5(2):99-106.
Pugazhenthi, S., et al. (1996) "Purification of Three Orally Active Hypoclycemic Compounds Kakara 1B, 111a, and 111b, from the Unripe Fruits of Momordica charantia" Linn (Bitter Gourd) Indian J. Clin. Biochem. 11(2):115-119.
Raman et al. "Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae)," Phytomedicine, vol. 2, No. 4, 349-362, 1996.
Reza-Ul-Jalil, et al. (1986) "Hypoglycemic Activities of the Glycosides of Momordica Cochinchinensis," J. Bangladesh Acad. Sci 10(1):25-30.
Sambrook et al. (1989) Molecular cloning: A Laboratory Manual, pp V-XXXII CSHL Press, Cold Spring Harbor, NY 2nd edition.
Sarkar et al. (1996) "Demonstration of the Hypoglycemic Action of Momordica Charantia in a Validated Animal Model of Diabetes," Pharmacol. Res. 33: 1-4.
Shibib et al., (1993) Biochem. J. 292: 267-270.
Medicherla Satyanarayana
Nag Bishwajit
Sharma Somesh D.
Calyx Therapeutics Inc.
Weber Jon P.
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