Surgery – Diagnostic testing – Cardiovascular
Patent
1995-10-05
1998-05-26
Jastrzab, Jeffrey R.
Surgery
Diagnostic testing
Cardiovascular
A61B 50468
Patent
active
057556717
ABSTRACT:
The method for assessing risk of an adverse clinical event includes detecting a physiologic signal in the subject and determining from the physiologic signal a sequence of intervals corresponding to time intervals between heart beats. The long-time structure of fluctuations in the intervals over a time period of more than fifteen minutes is analyzed to assess risk of an adverse clinical event. In a preferred embodiment, the physiologic signal is an electrocardiogram and the time period is at least fifteen minutes. A preferred method for analyzing the long-time structure variability in the intervals includes computing the power spectrum and fitting the power spectrum to a power law dependence on frequency over a selected frequency range such as 10.sup.-4 to 10.sup.-2 Hz. Characteristics of the long-time structure fluctuations in the intervals is used to assess risk of an adverse clinical event.
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Albrecht Paul
Bigger J. Thomas
Cohen Richard J.
Jastrzab Jeffrey R.
Massachusetts Institute of Technology
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