Solid pharmaceutical formulations for slow, zero order release v

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 22, A61K 922, A61K 926

Patent

active

043615457

ABSTRACT:
A new class of solid pharmaceutical formulations enables the attainment of slow, zero order in vivo release of a wide range of pharmaceutically active ingredients upon oral administration. A broad range of release rates can be preselected by suitable adjustments of tablet properties. The formulations are based upon control of active ingredient release from the surface of the tablet via a controlled surface erosion mechanism. These compositions comprise:

REFERENCES:
patent: 4264573 (1981-04-01), Powell et al.
Robinson, M. Chapter 14--Sustained Action Dosage Forms, pp. 439-465 in Lachman et al. (Ed.), The Theory and Practice of Industrial Pharmacy 2nd Ed. (1976) Lea & Febiger, Phila., Pa.

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