Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating

Details Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating Preparation of (8S)-8-fluoroerythromycins with N-F fluorinating

1994-09-14

1996-09-03

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 75, 536 181, C07H 1708, C07H 1524

Patent

active

055525334

ABSTRACT:
(8S)-8-fluoroerythromycins are prepared by reacting 8,9-anhydroerythromycin 6,9-hemiacetals or an N-oxide thereof with a carboxylic acid and an N-F fluorinating agent. The anhydro starting material may be prepared in situ from erythromycins or an N-oxide derivative thereof. The (8S)-8-fluoroerythromycin products are useful antibacterial agents.

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