Methods for using (2-imidazolin-2-ylamino) quinoxaline derivativ

Details Methods for using (2-imidazolin-2-ylamino) quinoxaline derivativ Methods for using (2-imidazolin-2-ylamino) quinoxaline derivativ

1994-10-31

1996-09-03

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 31495

Patent

active

055524036

ABSTRACT:
A method of treating a mammal comprises administering to a mammal an effective amount to provide a desired therapeutic effect in the mammal of a compound selected from the group consisting of those having the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R.sub.1 and R.sub.2 each is independently selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms, the 2-imidazolin-2-ylamino group may be in any of the 5-, 6-, 7- or 8-positions of the quinoxaline nucleus, and R.sub.3, R.sub.4 and R.sub.5 each is located in one of the remaining 5-, 6-, 7- or 8-positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals containing 1 to 3 carbon atoms. Such compounds, when administered to a mammal, provide treatment for ischemia.

REFERENCES:
patent: 3890319 (1975-06-01), Danielewicz et al.
patent: 4188393 (1980-02-01), Neuman
patent: 4656291 (1987-04-01), Maryanoff et al.
patent: 5021416 (1991-06-01), Gluchowski
patent: 5034406 (1991-07-01), Gluchowski
patent: 5077292 (1991-12-01), Gluchowski
patent: 5112822 (1992-05-01), Gluchowski
patent: 5130441 (1992-07-01), Gluchowski
patent: 5198442 (1993-03-01), Gluchowski
patent: 5204347 (1993-04-01), Gluchowski
patent: 5231096 (1993-07-01), Gluchowski
patent: 5237072 (1993-08-01), Gluchowski
Hamilton, C., Pharmac. Ther. vol. 54 (3) (1992) 231-248.
Williams et al, J. Auton. Pharmacol., 10 (4):247, Aug. 1990.
Fondacaro et al, Am. Soc. for Pharm., V 247, 1987.
Scrip Product Information, Scrip No. 1466, pp. 28, Nov. 1989.
Hildebrand et al, The Journal of Pharmacology & Exp. Ther., V. 263, No. 2, pp. 510-519, 1992.
Contiello et al, J. Biol. Chem., 264 (27), pp. 16000-16007, 1989.
Thaina et al, J. Auton Pharmacol, vol. 3, No. 2, pp. 115-126, Apr. 1993.
Hayes et al, Neuropharmacology, vol. 25, pp. 391-396, 1986.
Chemical Abstracts, vol. 98, 98:921, 1983.
Chemical Abstracts, 91:168403, 1979.
Walland, Chemical Abstracts, vol. 88, 164291p, 1978.
Philippu et al, Chemical Abstract, vol. 99: 11644m, 1983.
Ekas et al, Chemical Abstrcts, vol. 98: 210440t, 1983.
Steppeler et al, Chemical Abstracts, vol. 91: 168403m, 1979.
Steppeler et al, Chemical Abstracts, vol. 90: 33949c, 1979.
Timmermans et al, Chemical Abstracts, 89:474, 1978.
Boudier et al, Chemical Abstracts, vol. 82:106180, 1975.
Burke et al, Current Eye Research, Sep. 5(9): 665-76, 1986.
Mittag, Annals of Ophthalmology, 15(3), 201-202, 1983.
Fielding, Medicinal Research Reviews, vol. 1, No. 1, pp. 97-123, 1981.
Isom et al, The Journal of Biological Chemistry, vol. 262, No. 14, pp. 6750-6757, May 1987.
Pieter et al, Eur. J. Med. Chem., vol. 4, pp. 323-329, 1980.
Langer et al, Journal of Cardiovascular Pharm., vol. 7, Supp. 8 (S1-S8), 1988.
Nielsen et al, Br. J. Pharmacol, 97 (834), 1989.
B. Bloor, Seminars in Anesthesia, vol. VII, No. 3, pp. 170-177, Sep. 1988.
Sato et al, Science, vol. 251, pp. 1608-1610, Mar. 1991.
Gellai et al, The Journal of Pharmacology & Exp. Therap., 240(3), pp. 723-728, 1987.
Jarrot, Hardbook of Hypertension, vol. 5, pp. 113-168, 1984.
Bloor et al, Anesthesia & Analgesia, vol. 61, No. 9, 741-745, Sep. 1982.
Van Zwieten et al, Advances in Drug Research, vol. 13, 209-254, 1984.
Dharmsathaphorn, Gastroenterology, 91(3), 769-70, 1986.
Jumblatt et al., Current Eye Research, vol. 6, pp. 767-777, 1987.
Bendele et al, Pharmacol, 82, pp. 152, Aug. 1991.
Goodman and Gilman, The Pharmacological Basis of Therapeutics, 7th Ed., CH. 8, pp. 174-179, 1985.
Berridge et al, Br. J. Pharmac., 88(2), 345-354, 1986.
Thaina et al, J. Autonomic Pharmacology, 13(2), 95-176, 1993.
Gellai et al, Am. Physio. Soc., F317-323, 1988.
Colpaert, F. C., Drug Development Research, 7:209-220, 1986.
Dharmsathaphorn et al, Gastroenterology, 86(1), 120-128, 1984.
Hieble et al, The Pharmologist, 33(3), 214, 1991.
C. F. Colpaert, CA 105:481u, 1986.
Fondacaro, J. Pharmacol Exp. Ther., 247(2), pp. 481-486, Jul. 1988.

Affiliated with

Also associated with

Rating

Methods for using (2-imidazolin-2-ylamino) quinoxaline derivativ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for using (2-imidazolin-2-ylamino) quinoxaline derivativ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for using (2-imidazolin-2-ylamino) quinoxaline derivativ will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1950071