Huperzine A and analogs thereof

Details Huperzine A and analogs thereof Huperzine A and analogs thereof

1997-06-06

1999-02-09

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546153, 514290, A01N 5100, A61K 31655

Patent

active

058696725

ABSTRACT:
The present invention relates to a method for the synthesis of certain bridged fused ring pyridines. Such bridged fused ring pyridines can be converted to huperzine A and analogs of huperzine A. The present invention also covers such bridged fused ring pyridines, compounds utilized for the preparation of the bridged fused ring pyridines and analogs of huperzine A.

REFERENCES:
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C. M. Yu et al., Canadian Journal of Chemistry, 64, 837-839 (1986), The Structures of Huperzine A and B, Two New Alkaloids Exhibiting Marked Anticholinesterase Activity.
D. Gravel et al., Canadian Journal of Chemistry, 62, 2945-2947 (1984). Total Regiospecific Synthesis of Selagine Tricyclic Ring System.
W. Ye et al., Acta Pharmacologica Sinica, 9, 193-196 (1988), Pharmacokinetics of Huperzine A in Rats and Mice.
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A. Kende et al., Heterocycles, 21, 91-106, New Tactics in Heterocyclic Synthesis, 1984.
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Nyembo, CA 86:90108u of Bull. Chim. Belg. 1976 85(8), 595-604.

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