Process for preparing an angiotensin converting enzyme inhibitor

Details Process for preparing an angiotensin converting enzyme inhibitor Process for preparing an angiotensin converting enzyme inhibitor

1998-06-29

1999-02-09

Barts, Samuel

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548533, C07D21700

Patent

active

058696717

ABSTRACT:
A process for preparing an angiotensin converting enzyme inhibitor. Phosphorus pentachloride is reacted with the carboxylic acid group of an amino acid to form an acyl chloride hydrochloride. The resulting hydrochloride salt is then coupled with a silylated amino acid in a non-aqueous medium to form a high yield peptide. The peptide is used as an angiotensin converting enzyme (ACE) inhibitor.

REFERENCES:
patent: 4808741 (1989-02-01), Dudenes
patent: 5359086 (1994-10-01), Merslavic
Chem abstract 1988:187285; abstract of JP 62048655.

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