Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1998-01-02
1999-02-09
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540 2, 540576, 540581, 540612, C07D22314, B09B 300, C07C21770
Patent
active
058696520
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP 96/02734.
The present invention relates to a process for recovering active substances from unused or discarded devices for the transdermal application of active substances and/or their process waste, wherein the active substances contained in said devices are usually present in combination with polymeric films and polymeric sheets.
Devices for the transdermal application may be subdivided into two types: passive diffusion, and the action or by the aid of electric currents.
Systems based on passive diffusion are the so-called Transdermal Therapeutic Systems (TTS). They may be classified into the so-called matrix systems and the reservoir systems. In matrix systems, the active substance is dissolved in polymer films, or a certain portion is additionally suspended in crystalline-form or in the form of microcapsules. In the simplest case these systems therefore consist of a backing layer which is substantially impermeable to the active substance, the active substance-containing and preferably self-adhesive matrix, and a protective sheet to be removed prior to use.
Reservoir systems comprise the active substance in a fluid reservoir. The active substance may be present in a completely or only partially dissolved form. In the simplest case these systems consist of a backing layer which is impermeable to the substances contained in the reservoir, and a membrane at least permeable to the active substance and preferably provided with an adhesive film for skin application of the system.
Systems releasing the active substance to the skin or the organism under application of electric current may have various structures. They are particularly used for active substances which--owing to their chemico-physical properties--cannot penetrate the skin in a sufficient amount by means of passive diffusion. For known reasons an unspent active substance portion remains in each worn TTS. Such active substance-containing waste products represent a toxicological or ecological risk and must therefore be disposed of as hazardous waste at considerable expense. On the other hand, these waste products still contain very expensive and valuable ingredients or active substances originating from medicinal preparations, and in some cases it appears economically appropriate to recover these ingredients. One reason why the economic considerations to be taken into account in this connection are in favor of recovering active substances is that the support which is then substantially free of active substance is no longer regarded as hazardous waste and can therefore be disposed of at minimum cost.
The same applies to unused TTSs and their process waste, which inevitably results in some production methods, or to imperfect batches, which cannot always be avoided.
A number of recycling methods is known in the art, in particular recycling of waste products comprising adhesive-coated sheet material. DE 42 09 676, for example, describes a method of recycling pressure-sensitive self-adhesive material having an embossed stripfilm, in particular of PET-sheet material, laminated with ethylene-terephthalate-isophthalate copolyester. DE 42 21 681 describes a method of recycling polyethylene, polypropylene, or polystyrene adhesives on label waste products. DE 40 37 562 describes a recycling of adhesive-coated plastic films by repeated kneading in a solvent, drainage in a screw conveyor, and repeated passage of the remaining material in the same procedure.
DE 40 37 562 describes a process for recycling plastic sheets which are coated with adhesive and present in chip form by separating the plastic material and the adhesive. In a first stage, the sheet chips, placed in a solvent for the adhesive to disperse the adhesive adhering to the sheet chips, are agitated with the solvent for a predetermined period under mechanical action. Subsequently, the adhesive dispersed in the solvent is separated from the sheet shreds under mechanical action. In a second, similar stage fresh solvent is supplied to the sheet chips of the first stag
REFERENCES:
patent: 4543364 (1985-09-01), Nankee et al.
patent: 5288408 (1994-02-01), Schmidt et al.
patent: 5461147 (1995-10-01), Hou et al.
Asmussen Bodo
Hoffmann Hans-Rainer
Muller Walter
LTS Lohmann Therapie-Systeme GmbH
Shah Mukund J.
Sripada Pavanaram K.
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