Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-07-22
1999-02-09
Schwadron, Ronald B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 232, 4353201, 435325, 4352523, 43525411, 935 4, 935 11, 935 22, 935 66, C07H 2102, C07H 2104, C12N 1512, C12N 1563
Patent
active
058696377
ABSTRACT:
The present provides a polynucleotide which identifies and encodes a novel human kallikrein (HKLP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HKLP. The invention also provides for the use of substantially purified HKLP and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HKLP. Additionally, the invention provides for the use of antisense molecules to HKLP in pharmaceutical compositions for treatment of diseases associated with the expression of HKLP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HKLP or anti-HKLP antibodies which specifically bind to HKLP.
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Au-Young Janice
Bandman Olga
Braxton Scott Michael
Goli Surya K.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Schwadron Ronald B.
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