Method, reagents and kit for diagnosis and targeted screening fo

Details Method, reagents and kit for diagnosis and targeted screening fo Method, reagents and kit for diagnosis and targeted screening fo

1995-02-14

1996-09-03

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435 72, 435 71, 536 231, 536 243, 536 2431, 536 2432, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

055522831

ABSTRACT:
Rapid and cost effective diagnosis of p53 mutations of a sample of patients is achieved by employing a selected plurality of diagnostic tools, in a hierarchy of increasing accuracy and cost per tool, in which each tool detects essentially no false positives. Diagnostic tests that may be included among the plurality of tests selected include, in order of increasing accuracy and cost:

REFERENCES:
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4172124 (1979-10-01), Koprowski
patent: 4474893 (1984-10-01), Reading
patent: 4563419 (1986-01-01), Ranki et al.
patent: 4582788 (1986-04-01), Erlich
patent: 4683194 (1987-07-01), Saiki et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4811218 (1989-03-01), Hunkapiller
patent: 4823007 (1989-04-01), Hanson
patent: 4879214 (1989-11-01), Kornher et al.
patent: 4971903 (1990-11-01), Hyman
patent: 5062942 (1991-11-01), Kambara et al.
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5119316 (1992-06-01), Dam et al.
patent: 5122345 (1992-06-01), Tabor et al.
patent: 5137806 (1992-08-01), LeMaistre et al.
patent: 5227292 (1993-07-01), White et al.
patent: 5403707 (1995-04-01), Atwood et al.
Lambkin et al., "Variations in Immunohistochemical Detection of p53 Protein Overexpression in Cervical Carcinomas with Different Antibodies and Methods of Detection", J. Pathology 172:13-18 (1994).
Baas, et al. "An Evaluation of Six Antiboides for Immunohistochemistry of Mutant p53 Gene Product in Archival Colorectal Neoplasms", J. Pathology 172:5-12 (1994).
Hall et al., "p53 in Tumour Pathology: Can We Trust Immunohistochemistry--Revisited?", J. Pathology 172:1-4 (1994).
Rychlik, W., "Selection of Primers for Polymerase Chain Reaction", Methods in Molecular Biology, vol. 15: PCR Protocols: Current Methods and Applications, pp. 31-40 (1993).
Frebourg et al., "The Importance of p53 Gene Alterations in Human Cancer: Is There More Than Circumsatntial Evidence?", J. Nat'l Cancer Inst. 85:1554-1557 (1993).
Angelopoulou et al., "Prevalence of Serum Antibodies Against the p53 Tumor Suppressor Gene Protein in Various Cancers," Int. J. Cancer 58:480-487 (1994).
Donehower et al., "The Tumor Suppressor p53", Biochim. Biophys. Acta 1155:181-205 (1993).
Hassapoglidou et al., "Antibodies to the p53 Tumor Suppressor Gene Product Quantified in Cancer Pateint Serum with a Time-resolved Immunofluorometric Technique", Clin. Biochem. 25:445-449 (1992).
Harris et al, "Clinical Implications of the p53 Tumor Suppressor Gene", New Engl. J. Med. 329:1318-1327 (1993).
Breslauer et al., "Predicting DNA Duplex Stability from the Base Sequence", Proc. Nat'l Acad. Sci. 83:3746-3750 (1986).
Malkin et al., "Germline Mutations of the p53 Tumor-Suppressor Gene in Chiuldren and Young Adults with Second Malignant Neoplasms", New Engl. J. Med. 326:1309-1315 (1992).
Eisenstein, B. I., "The Polymerase Chain Reaction", N. Engl. J. Med. 322:178-183 (1990).
Erickson, D., "Diagnosis by DNA", Scientific American 267:116 (1992).
Toguchida et al., "Prevalence and Spectrum of Germline Mutations of the p53 Gene Among Patients With Sarcoma", New Engl. J. Med. 326:1301-1308 (1992).
Hatcher et al., "Heteroduplex Formation: A Potential Source of Genotyping Error from PCR Products", Prenatal Diagnosis 13:171-177 (1993).
Hassapoglidou et al., "Quantification of p53 Protein in Tumor Cell Lines, breast Tissue Extracts and Serum with Time-resolved Immunoflurometry", Oncogene 8:1501-1509 (1993).
Angelopoulou et al., "Autoantibodies against the p53 Tumor Suppressor Gene Product Quantified in Cancer Pateint Serum with Time-Resolved Immunoflurometry", The Cancer J. 6:315-321 (1993).
Ziegler et al., "Sunburn and p53 in the Onset of Skin Cancer", Nature 372:773-776 (1994).
Runnebaum et al., "Mutations in p53 as potentialmolecelar markers for human breast cancer." Proc. Natl. Acad. Sci. USA 88:10657-10661 (1991).
Chamberlain et al. "Detection of Gene Deletions Using Multiplex Polymerase Chain Reactions." Methods in Molecular Biology, Protocols in Human Molecular Genetics 9:299-319 (1991).
Dunn et al. "Tumor Suppressor Genes." Cellular Biochemistry Supp. 18c:199 (1994).
Runnebaum et al. PNAS 88:10657-10661 1991.
Kohler et al. Society of Gynecologic Oncologists Twenty Third Annual Meeting p. 40 1992.

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