Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-05-16
1999-02-09
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 3115
Patent
active
058695354
ABSTRACT:
A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
REFERENCES:
patent: 5468888 (1995-11-01), Bouboutou et al.
"Carcinostatics contg. betulin derivs.--having excellent antioncotic activities with less side affects," Chemical Abstracts, 89-204083/28, Dec. 1987.
Maurya et al., "Content of betulinic and betulin acid, antitumor agents of Zizyphus species," Fitoterapia, IX, No. 5, pp. 468-469, 1989.
Yasukawa et al., "Sterol and triterpene derivatives from plants inhibit the effects of a tumor promoter, and sitosterol and betulinic acid inhibit tumor formation in mouse skin two-stage carcinogenesis," Oncology, 48, pp. 72-76, 1991.
DasGupta Tapas K.
Kim Darrick S. H. L.
Pezzuto John M.
Goldberg Jerome D.
The Board of Trustees of the University of Illinois
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