Tricyclic benzazepine vasopressin antagonists

Details Tricyclic benzazepine vasopressin antagonists Tricyclic benzazepine vasopressin antagonists

1996-04-24

1999-02-09

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514213, 514215, 540587, 540576, A61K 3155, C07D22316

Patent

active

058694838

ABSTRACT:
Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.

REFERENCES:
patent: 5512563 (1996-04-01), Albright et al.
Albright et al, Chemical Abstract 123:313792 for Canadian Patent 2,128,955 (Jan. 30, 1995).
International Union of Pure and Applied Chemistry (IUPAC), vol. 82, 1960, p. 5566.
Drug Evaluations, 6th Ed. , 1986, Amer. Medical Assn. , pp. 160-162.
Cecil Textbook of Medicine, 19th Ed., 1992, Wynoaarden, M.D., Editor, pp. 2075-2079.
Yamamura, et al., Science, 252, pp. 572-574, 1991.
Yamamura, et al., Br. J. Pharmacol., 105, pp. 787-791 (1992).

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