Polymeric immunological adjuvants

Details Polymeric immunological adjuvants Polymeric immunological adjuvants

1994-02-15

1996-09-03

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4241931, 5147724, A61K 3900

Patent

active

055521410

ABSTRACT:
Adjuvants for enhancing the immune response to an antigen are provided comprising the adjuvant incorporated into a lipid layer where the adjuvant is covalently or non-covalently involved in a polymeric system. Conveniently, the adjuvant may be conjugated to a polymerizable group and co-polymerized with a water-soluble and/or amphiphilic polymerizable monomer or combined with a polymerized amphiphile. The adjuvant and antigen may then be administered to a mammalian host to obtain enhanced immune response.

REFERENCES:
patent: 4455142 (1984-06-01), Martins et al.
patent: 5312620 (1994-05-01), Ribi

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