Human coatomer vesicle protein

Details Human coatomer vesicle protein Human coatomer vesicle protein

1997-02-24

1999-02-09

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435 701, 435 711, 4352523, 4353201, 435325, 514 2, 530350, 536 235, 536 2431, C12Q 168, C07H 2104, C07K 1300

Patent

active

058692568

ABSTRACT:
The present invention provides a human coatomer vesicle protein (HECOP) and polynucleotides which identify and encode HECOP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HECOP and a method for producing HECOP. The invention also provides the use of HECOP and antagonists specifically binding HECOP in the prevention and treatment of diseases associated with expression of HECOP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HECOP.

REFERENCES:
Guo et al., J. Cell Biology 125(6), 1213-1224 (1994).
hara-Kuge et al., J. Cell Biology 124(6), 883-892 (1994).
Chow et al., Gene 169, 223-227 (1996).
Rothman, J.E., et al., "Protein Sorting by Transport Vesicles" Science (1996) 272:227-234.
Hara-Kuge, S., et al., "En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles." J.Cell Biol. (1994) 124:883-892. (GI 440389).
Guo, Q., et al., "Disruptions in Golgi Structure and Membrane Traffic in a Conditional Lethal Mammalian Cell Mutant Are Corrected by .epsilon.-COP." J.Cell Biol. (1994) 125(6):1213-1224. (GI 525196).

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