Mutation detecting method using photobridging-stabilized double-

Details Mutation detecting method using photobridging-stabilized double- Mutation detecting method using photobridging-stabilized double-

1994-07-25

1999-02-09

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, C12Q 168, C12P 1934

Patent

active

058692363

ABSTRACT:
A method for the detection of nucleic acid sequence variants is disclosed which method comprises the stabilization of a portion of the sequence by a covalent bond with a photoactivatable intercalating agent and compositions.

REFERENCES:
Sheffield et al, "Attachment of a 40-base-pair G+C-rich sequence (GC-clamp) to genomuc DNA fragments by the polymerase chain reaction results in improved detection of single-base changes", Proc. Natl. Acad Sciences, vol. 86, pp. 232-236 (Jan. 1989).
Costes et al, Human-Mol-Genet 2:393-397 (1993).
Am. J. Hum. Gent 51(4Supp):A217 (1992).

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