Novel 1-(4-piperidiniobenzyl)-2,3-dioxopiperazine derivatives or

Details Novel 1-(4-piperidiniobenzyl)-2,3-dioxopiperazine derivatives or Novel 1-(4-piperidiniobenzyl)-2,3-dioxopiperazine derivatives or

1982-02-22

1984-10-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544121, 544357, 544359, 544366, 544369, 544370, 544371, 544372, 544392, C07D40106, C07D24102

Patent

active

044776640

ABSTRACT:
A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

REFERENCES:
patent: 4110327 (1978-08-01), Sarkawa et al.
Hori et al., Chem. and Pharm. Bulletin, vol. 29, (3) pp. 684-698 (1981), (I).
Hori et al., Chem. and Pharm. Bulletin, vol. 29, (6) pp. 1594-1605, (1981), (II).

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