Pharmaceutically active salt derivative of 3-hydroxy-5-(hydroxym

Details Pharmaceutically active salt derivative of 3-hydroxy-5-(hydroxym Pharmaceutically active salt derivative of 3-hydroxy-5-(hydroxym

1985-11-13

1986-08-12

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40112, C07F 958

Patent

active

046057412

ABSTRACT:
The present invention relates to a novel pharmacologically active salt derivative, constituted by 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy-phenyl)-1-butanone 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphate, to the process for the production thereof, and to the related pharmaceutical compositions.
Said salt derivative is produced by reacting 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphoric acid with 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-3-butanone in an organic solvent and subsequently crystallizing the reaction product.
Said salt derivative carries out an important pharmacological activity as inhibitor of platelet aggregation with vasodilative action.

REFERENCES:
patent: 2828315 (1958-03-01), Wilson

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