Oligonucleotide derivatives

Details Oligonucleotide derivatives Oligonucleotide derivatives

1984-02-09

1986-08-12

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1910, C07H 1920

Patent

active

046057358

ABSTRACT:
Biotin- or 2,4-dinitrophenyl-oligodeoxyribonucleotide derivatve represented by the formula shown below and its preparation method is disclosed: ##STR1## wherein: R is ##STR2## m and n are each 0 or a natural number; R.sup.1 is a straight or branched hydrocarbon residue; and B is a base constituting the nucleotide (in which when a plural number of B exist, they may be either identical or different). This compound is useful for use as a nonradioactive affinity probe for nucleic acid or a primer.

REFERENCES:
patent: 4291024 (1981-09-01), Turcotte
patent: 4476301 (1984-10-01), Imbach et al.
Shigeko Nishmura et al., Synthetic Nucleosides and Nucleotides, XV..sup.1) 5-dimethylamino-2-oxidoisoquinolin-1yl Diazomethane: A Novel Water-Soluble Fluorescent Labelling Agent for Nucleotides, Chem. Pharm. Bull., Oct. 25, 1979, pp. 1695-1703.
W. J. Smagowicz et al., New Substrate Analogues for RNA Polymerase, Studia Biophysica, Berlin, vol. 81, 1980, No. 2/3 pp. 135-136.
Richard I. Gumport et al., T4 RNA ligase as a nucleic acid synthesis and modification reagent, Nucleac Acids Research, Symposium Series No. 7, 1980, pp. 167-171.
Pennia R. Langer et al., Enzymatic synthesis of biotin-labeled polynucleotides: Novel nucleic acid affinity probes, Proc. Natl. Acad Sci. USA, vol. 78, No. 11, pp. 6633-6637, Nov. 1981.
W. J. Smagowicz et al., Properties of P.sup.3 Esters of Nucleoside Triphosphates as Substrates for RNA Polymerase from Escherichia Coli, Biochemistry, 1981, vol. 20, No. 19, pp. 5538-5546.
R. Bruce Wallace, Hybridization of synthetic oligodeoxyribonucleotides to .phi..chi. 174 DNA: the effect of single base pair mismatch, Nucleic Acids Research, vol. 6, No. 11, 1979, pp. 3542-3557.
Brenda Connor et al., Detection of Sickle Cell .beta..sup.s -goblin allele by hybridization with synthetic oligonucleotides, Proc. Natl. Acad. Sci. USA, vol. 80, pp. 278-282, Jan. 1983.
Chemical Abstracts, vol. 94, No. 23, Jun. 8, 1981, p. 241, No. 187647x, Columbus, Ohio, W. J. Smagowicz et al., "New Substrate Analogs for RNA polymerase".
Chemical Abstracts, vol. 96, No. 7, Feb. 15, 1982, p. 207, (a) No. 47771z, P. Langer et al.: "Enzymic Synthesis of Biotin-labeled polynucleotides: novel nucleic acid affinity probes".

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