1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles

Details 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles

1978-07-14

1980-01-08

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424273P, C07D23112

Patent

active

041828950

ABSTRACT:
1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles, useful as anti-depressants and analgesics, are prepared by reduction with an alkali metal aluminum hydride of an .omega.[1-(3,4-diphenyl-1H-pyrazolyl)]-lower alkanamide; reduction with hydrogen in the presence of ammonia, methylamine, dimethylamine or diethylamine over a catalyst of a 1-(cyano-lower-alkyl)-3,4-diphenyl-1-H-pyrazole; reaction of a 1-(tosyloxy-lower-alkyl)-3,4-diphenyl-1H-pyrazole with a lower-alkylamine; reaction of 3,4-diphenylpyrazole with a halo-lower-alkylamine in the presence of an acid acceptor; or reductive alkylation with formaldehyde of a 1-(3-aminopropyl)-3,4-diphenyl-1H-pyrazole.

REFERENCES:
Grandberg et al., Zh. Obshch. Khim., 1961, vol. 31, pp. 3700-3705.
Torf et al., Chem. Abst., 1965, vol. 63, #16329e.
Noguchi et al., Chem. Abst., 1971, vol. 74, #22836g.
Jones et al., J. Org. Chem., 1954, vol. 19, pp. 1428-1434.
Buchi et al., Helv. Chim. Acta, 1955, vol. 38, pp. 670-679.
Rosenthal, Arch. intern. Pharmacodynamie, 1953, vol. 96, pp. 202-230.

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