Process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0.sup.3,

Details Process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0.sup.3, Process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0.sup.3,

1977-08-22

1980-01-08

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

26032611R, 2603265CA, 2603403, 424267, 544148, 544364, 544378, C07D49308

Patent

active

041828895

ABSTRACT:
A process for preparing 10-methyl-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decane derivatives is disclosed, wherein a 10-methylen-3-iodomethyl compound of the formula ##STR1## is hydrogenated to obtain a mixture of the corresponding epimeric 10.beta.- and 10.alpha.-methyl-3-iodomethyl compounds, the pure 10.alpha.- and 10.beta.-methyl epimers are separated and recovered from this mixture and are reacted with a secondary amine. Optionally, the substituent in the 4-position of the resulting 10.alpha.- or 10.beta.-methyl-3-aminomethyl compounds are further changed.

REFERENCES:
patent: 3812154 (1974-05-01), Thies
Chemical Abstracts, 80: 133654q (1974) [German Offen. 2,340,160; Bernauer et al., 2/21/74].
House, H., Modern Synthetic Reactions, 2nd. Ed., W. A. Benjamin, Inc., Menlo Park, Cal., 1972, p. 31.
Migrdichian, V., Organic Synthesis, vol. 1, Reinhold Pub. Corp., New York, 1957, p. 465.
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 591-592.
Schroter, R., in Newer Methods of Preparative Organic Chemistry, Interscience, New York, 1948, p. 92.

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