Chroman-2-ylmethylamino derivatives

Details Chroman-2-ylmethylamino derivatives Chroman-2-ylmethylamino derivatives

1996-04-10

1997-09-23

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31104

Patent

active

056706677

ABSTRACT:
Compounds of the formula: ##STR1## in which Z is hydrogen or a halogen; n is one of the integers 1, 2, 3, or 4; m is one of the integers 0 or 1; R is a substituted or unsubstituted aryl group in which the substituents are, independently, one or two members selected from the group consisting of alkyl, hydroxy, halo or amino groups; R.sup.2 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, are inhibitors of dopamine synthesis and release, useful in the treatment of schizophrenia, Parkinson's Disease, Tourette's Syndrome, alcohol addiction, cocaine addiction, and addiction to analagous drugs.

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patent: 5137901 (1992-08-01), Junge et al.
patent: 5318988 (1994-06-01), Schohe-Loop et al.
patent: 5371094 (1994-12-01), Heine et al.
Indian Journal of Chemistry, 20B, 12, 1063-1067, Dec. 1981, Pratap et al.

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