Pyranones

Details Pyranones Pyranones

1996-03-28

1997-09-23

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548235, 549292, C07D30930

Patent

active

056706626

ABSTRACT:
A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; and

REFERENCES:
patent: 4625039 (1986-11-01), Jewell, Jr. et al.
patent: 4957867 (1990-09-01), Minai et al.
patent: 5443971 (1995-08-01), Blacker et al.
Kimura, Y et al `Structure of a new fungal pyrone, from an unidentified Penicillium species` CA89:163347 (1978).
Meyer, H et al `Synthesis of some fungal metabolites with 4-methoxy-5,6-dihydro-2-pyrone structure` CA84:135415 (1976).
Cyr, TD et al `Pyrones. VIII. Biosynthetic investigations of the fungal metabolite phacidin` CA96:139446 (1982).
Tsubuki, M et al `Enantioselective synthesis of 6-substituted 5,6-dihydro alpha-pyranones (+)-goniothalamin and (-)-argentilactone` CA119:49083 (1993).
Cardani et al, Tetrahedron, 46(20):7283-7288 (1990).

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