Method for reversing multiple drug resistant phenotype

Details Method for reversing multiple drug resistant phenotype Method for reversing multiple drug resistant phenotype

1995-01-27

1997-09-23

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514274, 514299, 514310, 514315, 514418, A61K 3152, A61K 31565, A61K 3144, A61K 3147

Patent

active

056705077

ABSTRACT:
There is disclosed a method for reversing the multiple drug resistant (MDR) phenotype in tumors insensitive to hydrophobic chemotherapeutic drugs due to over expression of mdr-1, comprising administering an effective amount of a long chain amino alcohol compound. There is further disclosed a method for preventing the development of MDR during cancer chemotherapy treatments, comprising administering during cancer chemotherapy treatments an effective amount of a long chain amino alcohol compound.

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Chan et al., Hematology/Oncology Clinics North Amer.8:383, 1994.

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