Method of pretreating an animal with a corticosteroid prior to i

Details Method of pretreating an animal with a corticosteroid prior to i Method of pretreating an animal with a corticosteroid prior to i

1996-04-25

1997-09-23

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514759, A61K 3156

Patent

active

056704950

ABSTRACT:
This invention is directed to a method of attenuating or preventing the adverse side-effects of a perfluorochemical (PFC) emulsion on the hemostatic system and serum chemistry of an animal. The method includes intravenously administering a corticosteroid to an animal prior to intravenous administration of a PFC emulsion, in an amount sufficient to improve the adverse effects of the PFC upon the hemostatic system and serum triglyceride/enzyme levels of the animal. After administration of the corticosteroid, the PFC emulsion is administered intravenously. Preferably, the corticosteroid is dexamethasone, and the PFC is perfluorodichlorooctane.

REFERENCES:
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Rev. Fr. Transfus. Hemobiol., Les emulsions de fluorocarbures comme transporteurs d-oxyene injectables. Progres recents et perspectives, vol. 35, No. 6, pp. 391-406, 1992, Riess, J.G.
Blood, Activation of plasma complement by perfluorocarbon aritificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroid prophylaxis, vol. 59, No. 6, pp. 1299-1304, 1982, Vercellotti et al.
FASEB J., Prophylaxis with corticosteroids and cyclooxygenase inhibitors: effect on the delayed febrile response after intravenous infusion of perfluorochemical emulsions in conscious swine, vol. 6, No. 4, 1992, p. A1055, Abstract No. 689, Flaim et al.
Scanning Electron. Microscop., Endothelial response to perfluorochemical perfusion. vol. 1984/1, pp. 315-316, 1984, McCoy, L.E. et al.
S. F. Flaim, et al., "Characterization and Mechanism of Side Effects of Imagent BP (Highly Concentrated Fluorocarbon Emulsion) In Swine", vol. 26, Investigative Radiology, Nov. Supplement 1991, S122-S124.
Hainsey, B. M. et al. "Clinical Parameters of the Normal Baboons (Papio species) and Chimpanzees (Pan troglodytes)", vol. 43, No. 3, Laboratory Animal Science, Jun., 1993.
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