Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1984-12-17
1987-02-17
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
530324, 530350, C07K 510
Patent
active
046440550
ABSTRACT:
A general method for preparing specific inhibitors of virus-specified proteases is disclosed. The inhibitors comprise a halomethyl ketone or methyl ketone moiety covalently linked to a peptide sequence of three, four or five amino acids or amino acid residues, which peptide sequence corresponds to an amino acid sequence found adjacent to and upstream of a cleavage site recognized by a virus-specified protease.
REFERENCES:
patent: 4511504 (1985-04-01), McCullagh et al.
patent: 4518528 (1985-05-01), Rasnick
Korant, "Inhibition of Viral Protein Cleavage", in Antiviral Chemotherapy, Gauri, ed., (Academic Press, New York, 1981).
Korant, "Regulation of Animal Virus Replication by Protein Cleavage", in Proteases and Biological Control, (Cold Spring Harbor Laboratory, 1975).
Korant et al., "Picornaviruses and Togaviruses: Targets for Design of Antivirals", in Targets for the Design of Antiviral Agents, De Clercq et al., eds., (Plenum, New York, 1984).
Korant, J. Virol., 10:751-759 (1972).
Summers et al., J. Virol., 10:880-884 (1972).
Korant et al., Proc. Natl. Acad. Sci. USA, 76:2992-2995 (1979).
Lozitskii et al., Usp. Sovrem. Biol., 93:352-362 (1982).
Powers, "Haloketone Inhibitors of Proteolytic Enzymes", in Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, Weinstein, ed., (Marcel Dekker, New York, 1977) pp. 65-178.
Powers et al., Biochim. Biophys. Acta, 480:246-261 (1977).
Enzyme Systems Products: Nov. 1981 product bulletin.
Ito et al., Biochem. Biophys. Res. Commun., 49:343 (1972).
Fittkau et al., "Synthesis and Properties of Peptide Ketones", in Peptides 1982, Blaha et al., eds., (de Gruyter, New York, 1983) pp. 617-622.
Kettner Charles A.
Korant Bruce D.
E. I. Du Pont de Nemours and Company
Phillips Delbert R.
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