Inhibition of aldosterone secretion

Details Inhibition of aldosterone secretion Inhibition of aldosterone secretion

1984-08-17

1987-02-17

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3700

Patent

active

046439897

ABSTRACT:
Atrial peptides useful in practising the invention have the formula: ##STR1## wherein R.sub.1 is Arg, Leu-Arg, Ser-Leu-Arg, Arg-Ser-Leu-Arg, Pro-Arg-Ser-Leu-Arg, Gly-Pro-Arg-Ser-Leu-Arg, Ala-Gly-Pro-Arg-Ser-Leu-Arg or Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg; R.sub.17 is Met or Ile, R.sub.31 is Phe or desR.sub.31 ; R.sub.32 is Arg or desR.sub.32 ; R.sub.33 is Tyr or desR.sub.33 ; and Y is OH or NH.sub.2. These peptides or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, particularly humans, in order to inhibit basal aldosterone secretion and/or to manage aldosterone-dependent hypertention.

REFERENCES:
Atarashi et al., Science, 224, 992-994 (1984).
Chartier et al., Biochem. Bioph. Res. Comm., 122(1), 171-4 (1984).
Seidah et al., Proc. Natl. Acad. Sci., U.S.A., 81, 2640-44 (1984).
Rittel et al., Experientia, 32(2), 246 (1976).
Currie et al., Science, 221, 71-73 (1983).
Kangawa et al., Biochem, Biophy. Res. Comm., 118(1), 131-139 (1984).
Chemical Abstracts, 103 (1985) abst. No. 32467u.
De Lean et al., Endocrinology, 1984, vol. 115, No. 4, pp. 1636, 1637 & 1638.
Gutkowska et al., Proceedings of the Society for Experimental Biology and Medicine, 176, pp. 105-108 (1984).
Abstracts, 7th International Congress of Endocrinology, Jul. 1-7, 1984, Abstracts S.136, 488 & 1453, pp. 150, 504 & 987.

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